Article
The potential for beta-structure in the repeat domain of tau protein determines aggregation, synaptic decay, neuronal loss, and coassembly with endogenous Tau in inducible mouse models of tauopathy.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Jan 2008
Mocanu Maria-Magdalena, Nissen Astrid, Eckermann Katrin, Khlistunova Inna, Biernat Jacek, Drexler Dagmar, Petrova Olga, Schönig Kai, Bujard Hermann, Mandelkow Eckhard, Zhou Lepu, Rune Gabriele, Mandelkow Eva-Maria
Abstract excerpt
We describe two new transgenic mouse lines for studying pathological changes of Tau protein related to Alzheimer's disease. They are based on the regulatable expression of the four-repeat domain of human Tau carrying the FTDP17 (frontotemporal dementia and parkinsonism linked to chromosome 17) mu...
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