Article

Peptide-based inhibitors of Tau aggregation as a potential therapeutic for Alzheimer’s disease and other Tauopathies

2021-06-05

Abstract excerpt

<h4>ABSTRACT</h4> There are currently no disease altering drugs available for Tauopathies such as Alzheimer’s disease, which alone is predicted to affect ~88 million people worldwide by 2050. As Tau aggregation underpins its toxicity, aggregation inhibitors are likely to have disease-modifying potential. Guided by in-silico mutagenesis studies, we developed a potent retro-inverso peptide inhibitor of Tau aggregat...

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Literature Corpus work: e9276cf3-df6b-57b7-83e2-cdc82bb801dc
DOI: 10.1101/2021.06.04.447069

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