Article
Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.
The Biochemical journal - 1 May 2008
Zhou Qiong L, Jiang Zhen Y, Holik John, Chawla Anil, Hagan G Nana, Leszyk John, Czech Michael P
Abstract excerpt
Multiple studies have suggested that the protein kinase Akt/PKB (protein kinase B) is required for insulin-stimulated glucose transport in skeletal muscle and adipose cells. In an attempt to understand links between Akt activation and glucose transport regulation, we applied mass spectrometry-based proteomics and bioinformatics approaches to identify potential Akt substrates containing the phospho-Akt substrate...
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