Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.

The Biochemical journal - 15 Oct 2010

Vichaiwong Kanokwan, Purohit Suneet, An Ding, Toyoda Taro, Jessen Niels, Hirshman Michael F, Goodyear Laurie J

Abstract excerpt

TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab-GAP (GTPase-activating protein) that is highly expressed in skeletal muscle, but little is known about TBC1D1 regulation and function. We studied TBC1D1 phosphorylation on three predicted AMPK (AMP-activated protein kinase) phosphorylation sites (Ser231, Ser660 and Ser700) and one predicted Akt phosphorylation site (Thr590) in control mice, AMPKα2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aminoimidazole Carboxamide
Share to AMP-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Consensus Sequence

Share to Dietary Fats

Share to GTPase-Activating Proteins

Share to Muscle Contraction

Share to Phosphoserine

Share to Ribonucleotides

Source

Open in PubMed Open full text

Identifiers

PMID: 20701589
DOI: 10.1042/BJ20101100
PMCID: PMC2947193

Genes

USP6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Contraction regulates site-specific phosphorylation of TBC1D1 in skeletal muscle.PMID 20701589Read ↗

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.Semantic proximity Read ↗

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.Semantic proximity Read ↗

TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.Semantic proximity Read ↗

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.Semantic proximity Read ↗

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.Semantic proximity Read ↗

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.Semantic proximity Read ↗

Unbiased phosphoproteomics analysis unveils modulation of insulin signaling by extramitotic CDK1 kinase activity in human myotubesSemantic proximity Read ↗

Enhanced insulin signaling in human skeletal muscle and adipose tissue following gastric bypass surgery.Semantic proximity Read ↗

Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.Semantic proximity Read ↗

Myo1c regulates glucose uptake in mouse skeletal muscle.Semantic proximity Read ↗

The TBC1D1 gene: structure, function, and association with obesity and related traits.Semantic proximity Read ↗

Canonical and Alternative Pathways (Insulin and Exercise) of GLUT4 Synthesis, Signaling, Intracellular Clustering, and Recruitment to the Plasma MembraneSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.