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Article

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.

The Biochemical journal - 15 Jan 2008

Chen Shuai, Murphy Jane, Toth Rachel, Campbell David G, Morrice Nick A, Mackintosh Carol

Abstract excerpt

AS160 (Akt substrate of 160 kDa) and TBC1D1 are related RabGAPs (Rab GTPase-activating proteins) implicated in regulating the trafficking of GLUT4 (glucose transporter 4) storage vesicles to the cell surface. All animal species examined contain TBC1D1, whereas AS160 evolved with the vertebrates. TBC1D1 has two clusters of phosphorylated residues, either side of the second PTB (phosphotyrosine-binding domain)....

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Source

Identifiers

PMID: 17995453
DOI: 10.1042/BJ20071114

Genes

EGF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.PMID 17995453Read ↗

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