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Article

Identification of a novel phosphorylation site on TBC1D4 regulated by AMP-activated protein kinase in skeletal muscle.

American journal of physiology. Cell physiology - 1 Feb 2010

Treebak Jonas T, Taylor Eric B, Witczak Carol A, An Ding, Toyoda Taro, Koh Ho-Jin, Xie Jianxin, Feener Edward P, Wojtaszewski Jørgen F P, Hirshman Michael F, Goodyear Laurie J

Abstract excerpt

TBC1D4 (also known as AS160) regulates glucose transporter 4 (GLUT4) translocation and glucose uptake in adipocytes and skeletal muscle. Its mode of action involves phosphorylation of serine (S)/threonine (T) residues by upstream kinases resulting in inactivation of Rab-GTPase-activating protein (Rab-GAP) activity leading to GLUT4 mobilization. The majority of known phosphorylation sites on TBC1D4 lie within the...

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Identifiers

PMID: 19923418
DOI: 10.1152/ajpcell.00297.2009
PMCID: PMC2822490

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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