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Article

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice.

Diabetologia - 1 Feb 2017

Chen Qiaoli, Xie Bingxian, Zhu Sangsang, Rong Ping, Sheng Yang, Ducommun Serge, Chen Liang, Quan Chao, Li Min, Sakamoto Kei, MacKintosh Carol, Chen Shuai, Wang Hong Yu

Abstract excerpt

AIMS/HYPOTHESIS: TBC1D1 (tre-2/USP6, BUB2, cdc16 domain family member 1) is a Rab GTPase-activating protein (RabGAP) that has been implicated in regulating GLUT4 trafficking. TBC1D1 can be phosphorylated by the AMP-activated protein kinase (AMPK) on Ser231, which consequently interacts with 14-3-3 proteins. Given the key role for AMPK in regulating insulin-independent muscle glucose uptake, we hypothesised that...

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PMID: 27826658
DOI: 10.1007/s00125-016-4151-9

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USP6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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