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Article

The Inactivation of RabGAP Function of AS160 Promotes Lysosomal Degradation of GLUT4 and Causes Postprandial Hyperglycemia and Hyperinsulinemia.

Diabetes - 1 Nov 2016

Xie Bingxian, Chen Qiaoli, Chen Liang, Sheng Yang, Wang Hong Yu, Chen Shuai

Abstract excerpt

The AS160 (Akt substrate of 160 kDa) is a Rab-GTPase activating protein (RabGAP) with several other functional domains, and its deficiency in mice or human patients lowers GLUT4 protein levels and causes severe insulin resistance. How its deficiency causes diminished GLUT4 proteins remains unknown. We found that the deletion of AS160 decreased GLUT4 levels in a cell/tissue-autonomous manner. Consequently,...

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Source

Identifiers

PMID: 27554475
DOI: 10.2337/db16-0416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Research trail→

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The Inactivation of RabGAP Function of AS160 Promotes Lysosomal Degradation of GLUT4 and Causes Postprandial Hyperglycemia and Hyperinsulinemia.PMID 27554475Read ↗

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells.Semantic proximity Read ↗

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation.Semantic proximity Read ↗

AS160 regulates insulin- and contraction-stimulated glucose uptake in mouse skeletal muscle.Semantic proximity Read ↗

Mice with AS160/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking.Semantic proximity Read ↗

A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain.Semantic proximity Read ↗

Calmodulin binds to the Rab GTPase activating protein required for insulin-stimulated GLUT4 translocation.Semantic proximity Read ↗

Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney.Semantic proximity Read ↗

Rab10 in insulin-stimulated GLUT4 translocation.Semantic proximity Read ↗

Thr649Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle.Semantic proximity Read ↗

Akt substrate TBC1D1 regulates GLUT1 expression through the mTOR pathway in 3T3-L1 adipocytes.Semantic proximity Read ↗

Complementary regulation of TBC1D1 and AS160 by growth factors, insulin and AMPK activators.Semantic proximity Read ↗

Golgi-localized, gamma-ear-containing, Arf-binding protein adaptors mediate insulin-responsive trafficking of glucose transporter 4 in 3T3-L1 adipocytes.Semantic proximity Read ↗

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