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Article

Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.

The Biochemical journal - 15 Apr 2007

Roach William G, Chavez Jose A, Mîinea Cristinel P, Lienhard Gustav E

Abstract excerpt

Insulin stimulation of the trafficking of the glucose transporter GLUT4 to the plasma membrane is controlled in part by the phosphorylation of the Rab GAP (GTPase-activating protein) AS160 (also known as Tbc1d4). Considerable evidence indicates that the phosphorylation of this protein by Akt (protein kinase B) leads to suppression of its GAP activity and results in the elevation of the GTP form of a critical Rab....

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Identifiers

PMID: 17274760
DOI: 10.1042/BJ20061798
PMCID: PMC1874243

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Substrate specificity and effect on GLUT4 translocation of the Rab GTPase-activating protein Tbc1d1.PMID 17274760Read ↗

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