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Article

TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle.

Diabetes - 1 Jun 2010

An Ding, Toyoda Taro, Taylor Eric B, Yu Haiyan, Fujii Nobuharu, Hirshman Michael F, Goodyear Laurie J

Abstract excerpt

OBJECTIVE: TBC1D1 is a member of the TBC1 Rab-GTPase family of proteins and is highly expressed in skeletal muscle. Insulin and contraction increase TBC1D1 phosphorylation on phospho-Akt substrate motifs (PASs), but the function of TBC1D1 in muscle is not known. Genetic linkage analyses show a TBC1D1 R125W missense variant confers risk for severe obesity in humans. The objective of this study was to determine...

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Identifiers

PMID: 20299473
DOI: 10.2337/db09-1266
PMCID: PMC2874696

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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