Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.

BMC genetics - 14 Jan 2008

Sebastiani Paola, Zhao Zhenming, Abad-Grau Maria M, Riva Alberto, Hartley Stephen W, Sedgewick Amanda E, Doria Alessandro, Montano Monty, Melista Efthymia, Terry Dellara, Perls Thomas T, Steinberg Martin H, Baldwin Clinton T

Abstract excerpt

BACKGROUND: One of the challenges of the analysis of pooling-based genome wide association studies is to identify authentic associations among potentially thousands of false positive associations. RESULTS: We present a hierarchical and modular approach to the analysis of genome wide genotype data that incorporates quality control, linkage disequilibrium, physical distance and gene ontology to identify authentic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bayes Theorem
Share to Computational Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fetal Hemoglobin

Share to Genome, Human

Share to Linkage Disequilibrium

Share to Oligonucleotide Array Sequence Analysis

Share to Reproducibility of Results

Share to Sensitivity and Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 18194558
DOI: 10.1186/1471-2156-9-6
PMCID: PMC2248205

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A hierarchical and modular approach to the discovery of robust associations in genome-wide association studies from pooled DNA samples.PMID 18194558Read ↗

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.Semantic proximity Read ↗

Evaluating and improving power in whole-genome association studies using fixed marker sets.Semantic proximity Read ↗

A DNA pooling strategy for family-based association studies.Semantic proximity Read ↗

Bayesian method for gene detection and mapping, using a case and control design and DNA pooling.Semantic proximity Read ↗

Robust Inference With Ghostknockoffs in Genome-Wide Association Studies With Sample Relatedness.Semantic proximity Read ↗

Family history aggregation unit-based tests to detect rare genetic variant associations with application to the Framingham Heart Study.Semantic proximity Read ↗

DNA Pooling: a tool for large-scale association studies.Semantic proximity Read ↗

A pooling strategy to effectively use genotype data in quantitative traits genome-wide association studies.Semantic proximity Read ↗

Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes.Semantic proximity Read ↗

Unified tests for fine-scale mapping and identifying sparse high-dimensional sequence associations.Semantic proximity Read ↗

Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics.Semantic proximity Read ↗

A comparison of association statistics between pooled and individual genotypes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.