Article
A comparison of association statistics between pooled and individual genotypes.
Human heredity - 1 Jan 2009
Knight Jo, Saccone Scott F, Zhang Zhehao, Ballinger Dennis G, Rice John P
Abstract excerpt
BACKGROUND: Markers for individual genotyping can be selected using quantitative genotyping of pooled DNA. This strategy saves time and money. METHODS: To determine the efficacy of this approach, we investigated the bivariate distribution of association test statistics from pooled and individual genotypes. We used a sample of approximately 1,000 samples with individual and pooled genotyping on 40,000 SNPs....
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