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Article

Robust Inference With Ghostknockoffs in Genome-Wide Association Studies With Sample Relatedness.

Genetic epidemiology - 1 Sept 2026

Qi Xinran, Belloy Michael E, Gu Jiaqi, Liu Xiaoxia, Tang Hua, He Zihuai

Abstract excerpt

Genome-wide association studies (GWASs) have been extensively adopted to depict the underlying genetic architecture of complex traits. Recent studies show that knockoff-based methods can identify variants with unique, potentially causal effects on phenotypes. However, their statistical validity and effectiveness in studies with related individuals, such as the UK Biobank, remain unexplored. In this paper, we...

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PMID: 42569895
DOI: 10.1002/gepi.70051
PMCID: PMC13452088

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