Article
Extending rare-variant testing strategies: analysis of noncoding sequence and imputed genotypes.
American journal of human genetics - 12 Nov 2010
Zawistowski Matthew, Gopalakrishnan Shyam, Ding Jun, Li Yun, Grimm Sara, Zöllner Sebastian
Abstract excerpt
Next Generation Sequencing Technology has revolutionized our ability to study the contribution of rare genetic variation to heritable traits. However, existing single-marker association tests are underpowered for detecting rare risk variants. A more powerful approach involves pooling methods that combine multiple rare variants from the same gene into a single test statistic. Proposed pooling methods can be...
Topics
- Alleles
- Gene Frequency
- Genetic Association Studies
- Genetic Variation
- Genome-Wide Association Study
- Genotype
- Humans
- Models, Genetic
- RNA, Untranslated
- Risk
- Statistics as Topic