Article
Ancestry-specific associations identified in genome-wide combined-phenotype study of red blood cell traits emphasize benefits of diversity in genomics.
BMC genomics - 14 Mar 2020
Hodonsky Chani J, Baldassari Antoine R, Bien Stephanie A, Raffield Laura M, Highland Heather M, Sitlani Colleen M, Wojcik Genevieve L, Tao Ran, Graff Marielisa, Tang Weihong, Thyagarajan Bharat, Buyske Steve, Fornage Myriam, Hindorff Lucia A, Li Yun, Lin Danyu, Reiner Alex P, North Kari E, Loos Ruth J F, Kooperberg Charles, Avery Christy L
Abstract excerpt
BACKGROUND: Quantitative red blood cell (RBC) traits are highly polygenic clinically relevant traits, with approximately 500 reported GWAS loci. The majority of RBC trait GWAS have been performed in European- or East Asian-ancestry populations, despite evidence that rare or ancestry-specific variation contributes substantially to RBC trait heritability. Recently developed combined-phenotype methods which leverage...
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