Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.

doi:10.1086/510686

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Article

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.

American journal of human genetics - 1 Jan 2007

Pearson John V, Huentelman Matthew J, Halperin Rebecca F, Tembe Waibhav D, Melquist Stacey, Homer Nils, Brun Marcel, Szelinger Szabolcs, Coon Keith D, Zismann Victoria L, Webster Jennifer A, Beach Thomas, Sando Sigrid B, Aasly Jan O, Heun Reinhard, Jessen Frank, Kolsch Heike, Tsolaki Magdalini, Daniilidou Makrina, Reiman Eric M, Papassotiropoulos Andreas, Hutton Michael L, Stephan Dietrich A, Craig David W

Abstract excerpt

We report the development and validation of experimental methods, study designs, and analysis software for pooling-based genomewide association (GWA) studies that use high-throughput single-nucleotide-polymorphism (SNP) genotyping microarrays. We first describe a theoretical framework for establishing the effectiveness of pooling genomic DNA as a low-cost alternative to individually genotyping thousands of...

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PMID: 17160900
DOI: 10.1086/510686
PMCID: PMC1785308

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