Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A DNA pooling strategy for family-based association studies.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Apr 2005

Lee Wen-Chung

Abstract excerpt

Genome-wide association scans for disease susceptibility genes of complex diseases require genotyping on a massive scale. A DNA pooling strategy for family-based association studies is described, which is robust to population stratification biases and to errors in pooling. It can achieve a statistical efficiency of 0.95 with approximately 1 of 8 or fewer genotyping efforts, and an efficiency of 0.90 with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to DNA
Share to Gene Frequency

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Pool

Share to Genetics, Population

Share to Genotype

Share to Probability

Source

Identifiers

PMID: 15824170
DOI: 10.1158/1055-9965.EPI-04-0503

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A DNA pooling strategy for family-based association studies.PMID 15824170Read ↗

DNA Pooling: a tool for large-scale association studies.Semantic proximity Read ↗

DNA pooling as a tool for large-scale association studies in complex traits.Semantic proximity Read ↗

On the use of DNA pooling to estimate haplotype frequencies.Semantic proximity Read ↗

Identification of the genetic basis for complex disorders by use of pooling-based genomewide single-nucleotide-polymorphism association studies.Semantic proximity Read ↗

Design of DNA pooling to allow incorporation of covariates in rare variants analysis.Semantic proximity Read ↗

On optimal pooling designs to identify rare variants through massive resequencing.Semantic proximity Read ↗

Increasing the efficiency of genomic searches for linkage in complex disorders by DNA pooling of affected sib-pairs.Semantic proximity Read ↗

Design of association studies with pooled or un-pooled next-generation sequencing data.Semantic proximity Read ↗

Highly cost-efficient genome-wide association studies using DNA pools and dense SNP arrays.Semantic proximity Read ↗

Efficiency of DNA pooling to estimate joint allele frequencies and measure linkage disequilibrium.Semantic proximity Read ↗

Most pooling variation in array-based DNA pooling is attributable to array error rather than pool construction error.Semantic proximity Read ↗

Optimal DNA pooling-based two-stage designs in case-control association studies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.