Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiae.

PloS one - 1 Jan 2014

Yan Qing, Li Xiao-Ping, Tumer Nilgun E

Abstract excerpt

Ricin A chain (RTA) undergoes retrograde trafficking and is postulated to use components of the endoplasmic reticulum (ER) associated degradation (ERAD) pathway to enter the cytosol to depurinate ribosomes. However, it is not known how RTA evades degradation by the proteasome after entry into the cytosol. We observed two distinct trafficking patterns among the precursor forms of wild type RTA and nontoxic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytosol
Share to Endoplasmic Reticulum
Share to Endoplasmic Reticulum-Associated Degradation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Green Fluorescent Proteins

Share to Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase

Share to Ribosomes

Share to Vacuoles

Source

Open in PubMed Open full text

Identifiers

PMID: 25436896
DOI: 10.1371/journal.pone.0113719
PMCID: PMC4250064

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Wild type RTA and less toxic variants have distinct requirements for Png1 for their depurination activity and toxicity in Saccharomyces cerevisiae.PMID 25436896Read ↗

Ricin A chain utilises the endoplasmic reticulum-associated protein degradation pathway to enter the cytosol of yeast.Semantic proximity Read ↗

Ricin inhibits activation of the unfolded protein response by preventing splicing of the HAC1 mRNA.Semantic proximity Read ↗

Dependence of ricin toxicity on translocation of the toxin A-chain from the endoplasmic reticulum to the cytosol.Semantic proximity Read ↗

Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.Semantic proximity Read ↗

Free ricin A chain reaches an early compartment of the secretory pathway before it enters the cytosol.Semantic proximity Read ↗

Functional divergence between the two P1-P2 stalk dimers on the ribosome in their interaction with ricin A chain.Semantic proximity Read ↗

Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol.Semantic proximity Read ↗

A yeast killer toxin screen provides insights into a/b toxin entry, trafficking, and killing mechanisms.Semantic proximity Read ↗

Mistargeting of secretory cargo in retromer-deficient cells.Semantic proximity Read ↗

Cellular secretion and cytotoxicity of transthyretin mutant proteins underlie late-onset amyloidosis and neurodegeneration.Semantic proximity Read ↗

Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1.Semantic proximity Read ↗

STT3B-dependent posttranslational N-glycosylation as a surveillance system for secretory protein.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.