A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

doi:10.1016/s0092-8674(00)81360-4

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Article

A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.

Cell - 1 Nov 1996

Cox J S, Walter P

Abstract excerpt

Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER-resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway, the unfolded protein response (UPR). W...

Topics

Amino Acid Sequence
Basic-Leucine Zipper Transcription Factors
DNA, Fungal
Endopeptidases
Endoplasmic Reticulum
Fungal Proteins
Gene Expression Regulation, Fungal
Membrane Glycoproteins
Molecular Chaperones
Molecular Sequence Data
Phenotype
Protein Folding
Protein Serine-Threonine Kinases
RNA Splicing
RNA, Fungal
RNA, Messenger
Regulatory Sequences, Nucleic Acid
Repressor Proteins

Source

Open in PubMed

Identifiers

PMID: 8898193
DOI: 10.1016/s0092-8674(00)81360-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8898193-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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