Article
A novel mechanism for regulating activity of a transcription factor that controls the unfolded protein response.
Cell - 1 Nov 1996
Cox J S, Walter P
Abstract excerpt
Cells respond to an accumulation of unfolded proteins in the endoplasmic reticulum (ER) by increasing transcription of genes encoding ER-resident proteins. The information is transmitted from the ER lumen to the nucleus by an intracellular signaling pathway, the unfolded protein response (UPR). We have identified a basic-leucine zipper transcription factor, Hac1p, that is required for the UPR and binds to the UPR...
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