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Article

IRE1- and HAC1-independent transcriptional regulation in the unfolded protein response of yeast.

Molecular microbiology - 1 Aug 2003

Schröder Martin, Clark Robert, Kaufman Randal J

Abstract excerpt

The unfolded protein response (UPR) is a signalling pathway leading to transcriptional activation of genes that protect cells from accumulation of unfolded proteins in the lumen of the endoplasmic reticulum (ER). In yeast, the only known ER stress signalling pathway originates at the type I transmembrane protein kinase/endoribonuclease Ire1p. Ire1p regulates synthesis of the basic leucine-zipper (bZIP)-containing...

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PMID: 12864846
DOI: 10.1046/j.1365-2958.2003.03585.x

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