Article
Endoplasmic reticulum stress-induced mRNA splicing permits synthesis of transcription factor Hac1p/Ern4p that activates the unfolded protein response.
Molecular biology of the cell - 1 Oct 1997
Kawahara T, Yanagi H, Yura T, Mori K
Abstract excerpt
An intracellular signaling from the endoplasmic reticulum (ER) to the nucleus, called the unfolded protein response (UPR), is activated when unfolded proteins are accumulated in the ER under a variety of stress conditions ("ER stress"). We and others recently identified Hac1p/Ern4p as a transcrip...
Topics
- Base Sequence
- Basic-Leucine Zipper Transcription Factors
- Endoplasmic Reticulum
- Fungal Proteins
- Genes, Fungal
- Genetic Variation
- Leucine Zippers
- Mutation
- Protein Biosynthesis
- Protein Folding
- Proteins
- RNA Splicing
- RNA, Messenger
- Repressor Proteins
- Saccharomyces cerevisiae