Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.

Immunity - 1 Dec 2007

Agata Yasutoshi, Tamaki Nobuyuki, Sakamoto Shuji, Ikawa Tomokatsu, Masuda Kyoko, Kawamoto Hiroshi, Murre Cornelis

Abstract excerpt

Allelic exclusion of antigen-receptor genes is ensured primarily by monoallelic locus activation upon rearrangement and subsequently by feedback inhibition of continued rearrangement. Here, we demonstrated that the basic helix-loop-helix protein, E47, promoted T cell receptor beta (TCRbeta) gene rearrangement by directly binding to target gene segments to increase chromatin accessibility in a dosage-sensitive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Basic Helix-Loop-Helix Transcription Factors
Share to CD8-Positive T-Lymphocytes

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Feedback, Physiological

Share to Gene Rearrangement, T-Lymphocyte

Share to Genes, T-Cell Receptor beta

Share to Receptors, Antigen, T-Cell

Share to T-Lymphocytes

Share to TCF Transcription Factors

Source

Identifiers

PMID: 18093539
DOI: 10.1016/j.immuni.2007.11.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of T cell receptor beta gene rearrangements and allelic exclusion by the helix-loop-helix protein, E47.PMID 18093539Read ↗

Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.Semantic proximity Read ↗

Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus.Semantic proximity Read ↗

Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility.Semantic proximity Read ↗

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.Semantic proximity Read ↗

E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.Semantic proximity Read ↗

AIRE in context: Leveraging chromatin plasticity to trigger ectopic gene expression*Semantic proximity Read ↗

Epigenetic control of Tcrb gene rearrangement.Semantic proximity Read ↗

Gene segment selection in V(D)J recombination: accessibility and beyond.Semantic proximity Read ↗

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.Semantic proximity Read ↗

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.Semantic proximity Read ↗

RSSs set the odds for exclusion.Semantic proximity Read ↗

Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.