Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.

Abstract excerpt

A TCRβ enhancer, known as the Eβ enhancer, plays a critical role in V(D)J recombination and transcription of the Tcrb gene. However, the coordinated action of trans-acting factors in the activation of Eβ during T cell development remains uncharacterized. Here, we characterized the roles of Runx complexes in the regulation of the Eβ function. A single mutation at one of the two Runx binding motifs within the Eβ...

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• Share to Enhancer Elements, Genetic
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