Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.

Journal of immunology (Baltimore, Md. : 1950) - 15 Dec 2009

Bonnet Marie, Huang Fang, Benoukraf Touati, Cabaud Olivier, Verthuy Christophe, Boucher Anaelle, Jaeger Sébastien, Ferrier Pierre, Spicuglia Salvatore

Abstract excerpt

The TCRbeta gene enhancer (Ebeta) commands TCRbeta gene expression through the lifespan of T lymphocytes. Genetic and molecular studies have implied that in early thymocytes, Ebeta directs chromatin opening over the Dbeta-Jbeta-Cbeta domains and triggers initial Dbeta-Jbeta recombination. In mature T cells, Ebeta is required for expression of the assembled TCRbeta gene. Whether these separate activities rely on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer Elements, Genetic
Share to Gene Knock-In Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Rearrangement, beta-Chain T-Cell Antigen Receptor

Share to Hybridomas

Share to Immunoglobulin Variable Region

Share to Mice, Mutant Strains

Share to Models, Immunological

Share to Receptors, Antigen, T-Cell, alpha-beta

Source

Identifiers

PMID: 19923469
DOI: 10.4049/jimmunol.0902179

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Duality of enhancer functioning mode revealed in a reduced TCR beta gene enhancer knockin mouse model.PMID 19923469Read ↗

Gene-targeted deletion and replacement mutations of the T-cell receptor beta-chain enhancer: the role of enhancer elements in controlling V(D)J recombination accessibility.Semantic proximity Read ↗

Assessing the role of the T cell receptor beta gene enhancer in regulating coding joint formation during V(D)J recombination.Semantic proximity Read ↗

Deletion of the mouse T-cell receptor beta gene enhancer blocks alphabeta T-cell development.Semantic proximity Read ↗

Increase of TCR V beta accessibility within E beta regulatory region influences its recombination frequency but not allelic exclusion.Semantic proximity Read ↗

The T cell receptor beta enhancer promotes access and pairing of Dbeta and Jbeta gene segments during V(D)J recombination.Semantic proximity Read ↗

Distinct requirement of Runx complexes for TCRβ enhancer activation at distinct developmental stages.Semantic proximity Read ↗

Disruption of the lineage restriction of TCR beta gene rearrangements.Semantic proximity Read ↗

Enhancer control of V(D)J recombination at the TCRbeta locus: differential effects on DNA cleavage and joining.Semantic proximity Read ↗

E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.Semantic proximity Read ↗

The Ig(kappa) enhancer influences the ratio of Ig(kappa) versus Ig(lambda) B lymphocytes.Semantic proximity Read ↗

Molecular genetics at the T-cell receptor beta locus: insights into the regulation of V(D)J recombination.Semantic proximity Read ↗

Mechanisms of mu enhancer regulation in B lymphocytes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.