Article
Mutations that disrupt DNA binding and dimer formation in the E47 helix-loop-helix protein map to distinct domains.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jun 1990
Voronova A, Baltimore D
Abstract excerpt
A common DNA binding and dimerization domain containing an apparent "helix-loop-helix" (HLH) structure was recognized recently in a number of regulatory proteins, including the E47 and E12 proteins that bind to the kappa E2 motif in immunoglobulin kappa gene enhancer. The effect of site-directed...
Topics
- Amino Acid Sequence
- DNA
- DNA Probes
- DNA-Binding Proteins
- Enhancer Elements, Genetic
- Genes, Immunoglobulin
- Humans
- Immunoglobulin kappa-Chains
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Biosynthesis
- Protein Conformation
- Restriction Mapping
- TCF Transcription Factors
- Transcription Factor 7-Like 1 Protein
- Transcription Factors