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Article

E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2007

Wojciechowski Jason, Lai Anne, Kondo Motonari, Zhuang Yuan

Abstract excerpt

Thymocytes undergoing TCRbeta gene rearrangements are maintained in a low or nonproliferating state during early T cell development. This block in cell cycle progression is not released until the expression of a functional pre-TCR, which is composed of a successfully rearranged TCRbeta-chain and the Pre-Talpha-chain. The regulatory molecules responsible for the coordination of these differentiation and...

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Identifiers

PMID: 17442955
DOI: 10.4049/jimmunol.178.9.5717
PMCID: PMC2265380

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.PMID 17442955Read ↗

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