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Article

Nuclear export of histone deacetylase 7 during thymic selection is required for immune self-tolerance.

The EMBO journal - 28 Nov 2012

Kasler Herbert G, Lim Hyung W, Mottet Denis, Collins Amy M, Lee Intelly S, Verdin Eric

Abstract excerpt

Histone deacetylase 7 (HDAC7) is a T-cell receptor (TCR) signal-dependent regulator of differentiation that is highly expressed in CD4/CD8 double-positive (DP) thymocytes. Here, we examine the effect of blocking TCR-dependent nuclear export of HDAC7 during thymic selection, through expression of a signal-resistant mutant of HDAC7 (HDAC7-ΔP) in thymocytes. We find that HDAC7-ΔP transgenic thymocytes exhibit a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23103766
DOI: 10.1038/emboj.2012.295
PMCID: PMC3512390

Genes

HDAC7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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