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Article

RSSs set the odds for exclusion.

The Journal of experimental medicine - 7 Sept 2020

Krangel Michael S

Abstract excerpt

In this issue of JEM, Wu et al. (https://doi.org/10.1084/jem.20200412) provide new insights into allelic exclusion. They demonstrate that Vβ-to-DβJβ rearrangement occurs stochastically on two competing Tcrb alleles, with suboptimal Vβ recombination signal sequences limiting synchronous rearrangements and essential for allelic exclusion.

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Topics

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Share to Alleles
Share to Protein Sorting Signals
Share to Receptors, Antigen, T-Cell, alpha-beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Recombination, Genetic

Source

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Identifiers

PMID: 32793983
DOI: 10.1084/jem.20200831
PMCID: PMC7478726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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