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Article

Regulation of T cell receptor beta allelic exclusion at a level beyond accessibility.

Nature immunology - 1 Feb 2005

Jackson Annette, Kondilis Hrisavgi D, Khor Bernard, Sleckman Barry P, Krangel Michael S

Abstract excerpt

Allelic exclusion of V(beta)-to-DJ(beta) recombination depends on asynchronous rearrangement of alleles of the gene encoding T cell receptor beta in double-negative thymocytes and feedback inhibition that is maintained in double-positive thymocytes. Feedback is thought to be enforced through downregulation of V(beta) accessibility. In an attempt to override this negative regulation, we introduced the enhancer of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Antigen, T-Cell, alpha-beta

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Source

Identifiers

PMID: 15640803
DOI: 10.1038/ni1157

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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