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Article

Mechanisms for feedback inhibition of the immunoglobulin heavy chain locus.

Current opinion in immunology - 1 Apr 2004

Chowdhury Dipanjan, Sen Ranjan

Abstract excerpt

The production of immunoglobulin heavy chain (IgH) protein in pro-B cells provides feedback to terminate further V(H) gene recombination. This phenomenon is referred to as allelic exclusion. The chromatin structure of the V(H) genes regulates their recombination potential, hence alterations in chromatin are a key factor in allelic exclusion. In pro-B cells, IL-7/IL-7R signaling induces histone hyperacetylation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15023418
DOI: 10.1016/j.coi.2004.02.003

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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