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Article

Polymorphisms in the insulin like growth factor 1 and IGF binding protein 3 genes and risk of colorectal cancer.

Cancer detection and prevention - 1 Jan 2007

Pechlivanis Sonali, Wagner Kerstin, Chang-Claude Jenny, Hoffmeister Michael, Brenner Hermann, Försti Asta

Abstract excerpt

BACKGROUND: The insulin-like growth factor1 (IGF1) pathway plays a significant role in both the normal and malignant cell growth. IGF1 binds to the IGF1 receptor and starts a signaling cascade that regulates cell proliferation, differentiation, and apoptosis. The bioavailability of IGF1 is regulated by the binding protein IGFBP3. A CA repeat polymorphism, in the IGF1 gene, which is located 969 bp upstream from...

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Source

Identifiers

PMID: 18031946
DOI: 10.1016/j.cdp.2007.10.001

Genes

IGF1
IGFBP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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