Article
Association of IGF1 and IGFBP3 polymorphisms with colorectal polyps and colorectal cancer risk.
Cancer causes & control : CCC - 1 Jan 2010
Feik Elisabeth, Baierl Andreas, Hieger Barbara, Führlinger Gerhard, Pentz Astrid, Stättner Stefan, Weiss Werner, Pulgram Thomas, Leeb Gernot, Mach Karl, Micksche Michael, Gsur Andrea
Abstract excerpt
PURPOSE: Insulin-like growth factor 1 (IGF1) is a peptide growth factor that promotes cell proliferation and inhibits apoptosis. The bioavailability of IGF1 is regulated by the insulin-like growth factor binding protein 3 (IGFBP3). The purpose of this study was to examine the association of genetic variants in IGF1 (rs6214, rs6220, and rs35767) and IGFBP3 (rs2854744 and rs2854746) with risk of colorectal polyps...