Article
Circulating Levels of Insulin-like Growth Factor 1 and Insulin-like Growth Factor Binding Protein 3 Associate With Risk of Colorectal Cancer Based on Serologic and Mendelian Randomization Analyses.
Gastroenterology - 1 Apr 2020
Murphy Neil, Carreras-Torres Robert, Song Mingyang, Chan Andrew T, Martin Richard M, Papadimitriou Nikos, Dimou Niki, Tsilidis Konstantinos K, Banbury Barbara, Bradbury Kathryn E, Besevic Jelena, Rinaldi Sabina, Riboli Elio, Cross Amanda J, Travis Ruth C, Agnoli Claudia, Albanes Demetrius, Berndt Sonja I, Bézieau Stéphane, Bishop D Timothy, Brenner Hermann, Buchanan Daniel D, Onland-Moret N Charlotte, Burnett-Hartman Andrea, Campbell Peter T, Casey Graham, Castellví-Bel Sergi, Chang-Claude Jenny, Chirlaque María-Dolores, de la Chapelle Albert, English Dallas, Figueiredo Jane C, Gallinger Steven J, Giles Graham G, Gruber Stephen B, Gsur Andrea, Hampe Jochen, Hampel Heather, Harrison Tabitha A, Hoffmeister Michael, Hsu Li, Huang Wen-Yi, Huyghe Jeroen R, Jenkins Mark A, Keku Temitope O, Kühn Tilman, Kweon Sun-Seog, Le Marchand Loic, Li Christopher I, Li Li, Lindblom Annika, Martín Vicente, Milne Roger L, Moreno Victor, Newcomb Polly A, Offit Kenneth, Ogino Shuji, Ose Jennifer, Perduca Vittorio, Phipps Amanda I, Platz Elizabeth A, Potter John D, Qu Conghui, Rennert Gad, Sakoda Lori C, Schafmayer Clemens, Schoen Robert E, Slattery Martha L, Tangen Catherine M, Ulrich Cornelia M, van Duijnhoven Franzel J B, Van Guelpen Bethany, Visvanathan Kala, Vodicka Pavel, Vodickova Ludmila, Vymetalkova Veronika, Wang Hansong, White Emily, Wolk Alicja, Woods Michael O, Wu Anna H, Zheng Wei, Peters Ulrike, Gunter Marc J
Abstract excerpt
BACKGROUND & AIMS: Human studies examining associations between circulating levels of insulin-like growth factor 1 (IGF1) and insulin-like growth factor binding protein 3 (IGFBP3) and colorectal cancer risk have reported inconsistent results. We conducted complementary serologic and Mendelian randomization (MR) analyses to determine whether alterations in circulating levels of IGF1 or IGFBP3 are associated with...
Read the complete abstract on PubMed