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Article

Circulating protein levels of insulin-like growth factor 1 signaling pathway and the predisposition to colorectal carcinogenesis: a systematic review and meta-analysis.

BMC cancer - 29 Dec 2025

Naderi Noukabadi Fatemeh, Daskar Abkenar Elahe, Tierling Sascha, Shojaee Sajad, Ashtari Sara, Sadeghi Amir, Fatemi Nayeralsadat

Abstract excerpt

BACKGROUND: The insulin-like growth factor (IGF) family plays a critical role in cancer progression, with the insulin-like growth factor-1 receptor IGF-1Rsignificantly regulating cellular growth through specific signaling pathways. These pathways may enhance cell proliferation and colorectal cancer (CRC) advancement. Some studies suggest an association between serum IGF levels and reduced CRC risk. To further...

Topics

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Biomarkers, Tumor
Carcinogenesis
Colorectal Neoplasms
Insulin-Like Growth Factor Binding Protein 3
Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Insulin-Like Growth Factor II

Insulin Receptor Substrate Proteins

Receptor, IGF Type 1

Source

Open in PubMed Open full text

Identifiers

PMID: 41466239
DOI: 10.1186/s12885-025-15496-9
PMCID: PMC12892816

Genes

IGFBP3
IGF1
IRS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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