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Is there an association between variants in candidate insulin pathway genes IGF-I, IGFBP-3, INSR, and IRS2 and risk of colorectal cancer in the Iranian population?

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2013

Karimi Khatoon, Mahmoudi Touraj, Karimi Negar, Dolatmoradi Hesamodin, Arkani Maral, Farahani Hamid, Vahedi Mohsen, Parsimehr Elham, Dabiri Reza, Nobakht Hossein, Asadi Asadollah, Zali Mohammad Reza

Abstract excerpt

BACKGROUND: Several epidemiological studies have shown associations between colorectal cancer (CRC) risk and type 2 diabetes and obesity. Any effects would be expected to be mediated through the insulin pathway. Therefore it is possible that variants of genes encoding components of the insulin pathway play roles in CRC susceptibility. In this study, we hypothesized that polymorphisms in the genes involving the...

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Source

Identifiers

PMID: 24175768
DOI: 10.7314/apjcp.2013.14.9.5011

Genes

IRS2
INSR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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