Article
Polymorphisms of genes coding for insulin-like growth factor 1 and its major binding proteins, circulating levels of IGF-I and IGFBP-3 and breast cancer risk: results from the EPIC study.
British journal of cancer - 30 Jan 2006
Canzian F, McKay J D, Cleveland R J, Dossus L, Biessy C, Rinaldi S, Landi S, Boillot C, Monnier S, Chajès V, Clavel-Chapelon F, Téhard B, Chang-Claude J, Linseisen J, Lahmann P H, Pischon T, Trichopoulos D, Trichopoulou A, Zilis D, Palli D, Tumino R, Vineis P, Berrino F, Bueno-de-Mesquita H B, van Gils C H, Peeters P H M, Pera G, Ardanaz E, Chirlaque M-D, Quirós J R, Larrañaga N, Martínez-García C, Allen N E, Key T J, Bingham S A, Khaw K-T, Slimani N, Norat T, Riboli E, Kaaks R
Abstract excerpt
Insulin-like growth factor I (IGF-I) stimulates cell proliferation and can enhance the development of tumours in different organs. Epidemiological studies have shown that an elevated level of circulating IGF-I is associated with increased risk of breast cancer, as well as of other cancers. Most of circulating IGF-I is bound to an acid-labile subunit and to one of six insulin-like growth factor binding proteins...
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