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Article

Genetic Variants in the Insulin-like Growth Factor Pathway and Colorectal Cancer Risk in the Netherlands Cohort Study.

Scientific reports - 18 Sept 2015

Simons Colinda C J M, Schouten Leo J, Godschalk Roger W L, van Engeland Manon, van den Brandt Piet A, van Schooten Frederik J, Weijenberg Matty P

Abstract excerpt

Interrelationships between insulin-like growth factors (IGFs), hyperinsulinaemia, diabetes, and colorectal cancer (CRC) indicate involvement of IGFs in colorectal tumorigenesis. We investigated the CRC risk associated with 24 single nucleotide polymorphisms (SNPs) in 9 genes related to the IGF pathway and an IGF1 19-CA repeat polymorphism. Variants were selected from literature and genotyped in toenail DNA from...

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PMID: 26381944
DOI: 10.1038/srep14126
PMCID: PMC4585376

Genes

IGF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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