Article
Polymorphisms in the IGF-1 and IGFBP 3 promoter and the risk of breast cancer.
Breast cancer research and treatment - 1 Jul 2005
Wagner Kerstin, Hemminki Kari, Israelsson Elisabeth, Grzybowska Ewa, Söderberg Magnus, Pamula Jolanta, Pekala Wioletta, Zientek Helena, Mielzynska Danuta, Siwinska Ewa, Försti Asta
Abstract excerpt
Binding of IGF-1 to the type I IGF receptor starts a signalling cascade that plays an important role in regulating cell proliferation, differentiation and apoptosis. The interaction between the IGF-1 and its receptor is mainly regulated by a binding protein, IGFBP 3. We studied a CA repeat polymorphism 969 bp upstream of the transcription start site in the IGF-1 gene and an A-202 C polymorphism in the IGFBP 3...
Topics
- Adult
- Aged
- Breast Neoplasms
- Case-Control Studies
- Female
- Finland
- Gene Frequency
- Genetic Predisposition to Disease
- Humans
- Insulin-Like Growth Factor Binding Protein 3
- Insulin-Like Growth Factor I
- Middle Aged
- Poland