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Article

Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice.

Environmental and molecular mutagenesis - 1 Dec 2007

Bendre Sachin V, Shaddock Joseph G, Dobrovolsky Vasily N, Albertini Richard J, Heflich Robert H

Abstract excerpt

Azathioprine (Aza), a prodrug of 6-mercaptopurine, is used in human medicine to prevent transplant rejection and for the treatment of autoimmune diseases. Extremely high HPRT lymphocyte mutant frequencies (MFs) are found in humans and mice chronically treated with Aza, and these elevated MFs appear to be caused by selection and amplification of pre-existing HPRT mutant lymphocytes. In the present study, we...

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Identifiers

PMID: 18008354
DOI: 10.1002/em.20352

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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