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Article

Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine.

Mutagenesis - 1 Sept 2000

Meng Q, Grosovsky A J, Shi X, Walker V E

Abstract excerpt

Previous experiments in our research group showed that 3'-azido-3'-deoxythymidine (AZT) caused increased mutant frequencies (Mfs) at the X-linked hypoxanthine-guanine phosphoribosyltransferase (HPRT) and the autosomal thymidine kinase (TK) genes in human lymphoblastoid cells and that there was a significant positive correlation between AZT incorporation into cellular DNA and AZT-induced TK Mfs. In the current...

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Source

Identifiers

PMID: 10970446
DOI: 10.1093/mutage/15.5.405

Genes

APRT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Mutagenicity and loss of heterozygosity at the APRT locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine.PMID 10970446Read ↗

Isolation of an APRT heterozygote from TK6 human lymphoblasts: predominance of multi-locus loss of heterozygosity among spontaneous APRT-mutants.Semantic proximity Read ↗

Relationships between DNA incorporation, mutant frequency, and loss of heterozygosity at the TK locus in human lymphoblastoid cells exposed to 3'-azido-3'-deoxythymidine.Semantic proximity Read ↗

Allelic losses in mutations at the aprt locus of human lymphoblastoid cells.Semantic proximity Read ↗

Carcinogen-induced loss of heterozygosity at the Aprt locus in somatic cells of the mouse.Semantic proximity Read ↗

Heritable alterations at the adenine phosphoribosyltransferase (APRT) locus in human lymphoblastoid cell lines.Semantic proximity Read ↗

Molecular analysis of mutations at the HPRT and TK loci of human lymphoblastoid cells after combined treatments with 3'-azido-3'-deoxythymidine and 2',3'-dideoxyinosinedagger.Semantic proximity Read ↗

Determination of spontaneous loss of heterozygosity mutations in Aprt heterozygous mice.Semantic proximity Read ↗

Reduction to homozygosity is the predominant spontaneous mutational event in cultured human lymphoblastoid cells.Semantic proximity Read ↗

Intervention of somatic mutational events in vivo by a germline defect at the adenine phosphoribosyltransferase locus.Semantic proximity Read ↗

Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine.Semantic proximity Read ↗

Complex chromosomal mechanisms lead to APRT loss of heterozygosity in heteroploid cells.Semantic proximity Read ↗

Similarity of in vivo somatic mutations at an autosomal adenine phosphoribosyltransferase locus between T- and B-cells in human peripheral blood.Semantic proximity Read ↗

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