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Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine.

Mutation research - 15 Oct 2005

Bendre Sachin V, Shaddock Joseph G, Patton Ralph E, Dobrovolsky Vasily N, Albertini Richard J, Heflich Robert H

Abstract excerpt

Many patients undergoing chronic therapy with the purine analogue Azathioprine (Aza) have highly elevated HPRT lymphocyte mutant frequencies (MFs), and it is likely that these increases are due to selection of pre-existing HPRT mutant lymphocytes. A similar selection in germ cells might result in...

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Identifiers

PMID: 16107271
DOI: 10.1016/j.mrfmmm.2004.09.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16107271-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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