Article
Frequency of Tk and Hprt lymphocyte mutants and bone marrow micronuclei in B6C3F(1)/Tk+/- mice treated neonatally with zidovudine and lamivudine.
Carcinogenesis - 1 Sept 2002
Von Tungeln Linda S, Hamilton L Patrice, Dobrovolsky Vasily N, Bishop Michelle E, Shaddock Joseph G, Heflich Robert H, Beland Frederick A
Abstract excerpt
Mother-to-child transmission of the human immunodeficiency virus is substantially reduced by prenatal and postnatal treatment with anti-retroviral nucleoside analogues; however, the long-term consequences of these drug interventions are not known. The nucleoside analogue zidovudine (3'-azido-2',3'-dideoxythymidine; AZT) is carcinogenic in mice when administered transplacentally or neonatally, and this may be due...
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