Age dependent selection against HPRT deficient T lymphocytes in the HPRT+/- heterozygous mouse.

doi:10.1016/0027-5107(95)00214-6

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Article

Age dependent selection against HPRT deficient T lymphocytes in the HPRT+/- heterozygous mouse.

Mutation research - 26 Mar 1996

Deubel W, Bassukas I D, Schlereth W, Lorenz R, Hempel K

Abstract excerpt

The fraction of HPRT deficient T lymphocytes was measured in the HPRT +/- female mouse between birth and an age of about 2 years. The animals were the F1 offspring of the HPRT deficient strain 129MF1 and HPRT competent C57BL/6J-mice. T lymphocytes from spleen were cloned in vitro and HPRT deficie...

Topics

Aging
Animals
Female
Heterozygote
Hypoxanthine Phosphoribosyltransferase
Mice
Models, Biological
Mutation
T-Lymphocytes

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