Article
Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse.
Environmental and molecular mutagenesis - 1 Jan 1999
Smith C C, Archer G E, Forster E J, Lambert T R, Rees R W, Lynch A M
Abstract excerpt
The mutagenicity and clastogenicity of the immunosuppressive drug azathioprine (AZA), a multitissue rodent carcinogen and IARC-classified human carcinogen, was investigated using transgenic lacZ mice (MutaMouse). Male animals (n = 5 per group) were dosed with AZA (10, 50, 100 mg/kg p.o. daily for 5 days), vehicle (n = 10), or the positive control, chlorambucil (15 mg/kg i.p., n = 3), and killed 24 hr or 25 days...
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