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Article

Longitudinal study of frequency of HPRT mutant T cells in patients with multiple sclerosis.

Neurology - 1 Feb 1994

Sriram S

Abstract excerpt

Analysis of somatic mutation in circulating peripheral blood T cells can be used as an index of in vivo T-cell amplification. The ability to assess the frequency of T cells that survive in vitro in the presence of 6-thioguanine is an index of mutation at the HPRT gene locus. In the absence of exposure to mutational agents, elevations of the HPRT mutant frequency (mF) of T cells reflects errors in DNA replication...

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Source

Identifiers

PMID: 8309581
DOI: 10.1212/wnl.44.2.311

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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