Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model.

Oncotarget - 22 Sept 2015

Bodo Sahra, Svrcek Magali, Sourrouille Isabelle, Cuillières-Dartigues Peggy, Ledent Tatiana, Dumont Sylvie, Dinard Laetitia, Lafitte Philippe, Capel Camille, Collura Ada, Buhard Olivier, Wanherdrick Kristell, Chalastanis Alexandra, Penard-Lacronique Virginie, Fabiani Bettina, Fléjou Jean-François, Brousse Nicole, Beaugerie Laurent, Duval Alex, Muleris Martine

Abstract excerpt

Mismatch-repair (MMR)-deficient cells show increased in vitro tolerance to thiopurines because they escape apoptosis resulting from MMR-dependent signaling of drug-induced DNA damage. Prolonged treatment with immunosuppressants including azathioprine (Aza), a thiopurine prodrug, has been suggested as a risk factor for the development of late onset leukemias/lymphomas displaying a microsatellite instability (MSI)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Azathioprine
Share to DNA Mismatch Repair

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunosuppressive Agents

Share to Inflammatory Bowel Diseases

Share to Kaplan-Meier Estimate

Share to Lymphoma

Share to Microsatellite Instability

Share to MutS Homolog 2 Protein

Source

Open in PubMed Open full text

Identifiers

PMID: 26327213
DOI: 10.18632/oncotarget.4638
PMCID: PMC4694807

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Azathioprine induction of tumors with microsatellite instability: risk evaluation using a mouse model.PMID 26327213Read ↗

Azathioprine-induced carcinogenesis in mice according to Msh2 genotype.Semantic proximity Read ↗

Thiopurines, DNA damage, DNA repair and therapy-related cancerSemantic proximity Read ↗

Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse.Semantic proximity Read ↗

Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability.Semantic proximity Read ↗

DNA mismatch repair deficiency stimulates N-ethyl-N-nitrosourea-induced mutagenesis and lymphomagenesis.Semantic proximity Read ↗

The mechanisms underlying MMR deficiency in immunodeficiency-related non-Hodgkin lymphomas are different from those in other sporadic microsatellite instable neoplasms.Semantic proximity Read ↗

Apoptosis and mutation in the murine small intestine: loss of Mlh1- and Pms2-dependent apoptosis leads to increased mutation in vivo.Semantic proximity Read ↗

Lymphocyte Hprt mutant frequency and sperm toxicity in C57BL/6 mice treated chronically with Azathioprine.Semantic proximity Read ↗

Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene.Semantic proximity Read ↗

Methotrexate induces oxidative DNA damage and is selectively lethal to tumour cells with defects in the DNA mismatch repair gene MSH2Semantic proximity Read ↗

Cell lineage-specific effects associated with multiple deficiencies of tumor susceptibility genes in Msh2(-/-)Rb(+/-) mice.Semantic proximity Read ↗

Effect of chronic azathioprine treatment on germ-line transmission of Hprt mutation in mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.