Article
Frequency of Hprt mutant lymphocytes and micronucleated erythrocytes in p53-haplodeficient mice treated perinatally with AZT and AZT in combination with 3TC.
Environmental and molecular mutagenesis - 1 Jan 2000
Dobrovolsky Vasily N, Shaddock Joseph G, Mittelstaedt Roberta A, Bishop Michelle E, Lewis Sherry M, Lee Fei W, Aidoo Anane, Leakey Julian E A, Dunnick June K, Heflich Robert H
Abstract excerpt
Azidothymidine (AZT) is a nucleoside reverse transcriptase inhibitor (NRTI) that is used for reducing mother-to-child transmission of human immunodeficiency virus I. Combinations of AZT and 3'-thiacytidine (3TC) are even more effective than AZT alone. AZT, however, is a mutagen and carcinogen in...
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