Article
Mutagenicity of zidovudine, lamivudine, and abacavir following in vitro exposure of human lymphoblastoid cells or in utero exposure of CD-1 mice to single agents or drug combinations.
Environmental and molecular mutagenesis - 1 Jan 2000
Torres Salina M, Walker Dale M, Carter Meghan M, Cook Dennis L, McCash Consuelo L, Cordova Edmund M, Olivero Ofelia A, Poirier Miriam C, Walker Vernon E
Abstract excerpt
Experiments were performed to investigate the impact of zidovudine (AZT), lamivudine (3TC), and abacavir (ABC) on cell survival and mutagenicity in two reporter genes, hypoxanthine-guanine phosphoribosyltransferase (HPRT) and thymidine kinase (TK), using cell cloning assays for assessing the effects of individual drugs/drug combinations in (1) TK6 human lymphoblastoid cells exposed in vitro and (2) splenic...
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