Article
Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.
Cell - 2 Nov 2007
Pospisilik J Andrew, Knauf Claude, Joza Nicholas, Benit Paule, Orthofer Michael, Cani Patrice D, Ebersberger Ingo, Nakashima Tomoki, Sarao Renu, Neely Gregory, Esterbauer Harald, Kozlov Andrey, Kahn C Ronald, Kroemer Guido, Rustin Pierre, Burcelin Remy, Penninger Josef M
Abstract excerpt
Type-2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion. Recent studies place altered mitochondrial oxidative phosphorylation (OxPhos) as an underlying genetic element of insulin resistance. However, the causative or compensatory nature of these OxPhos changes has yet to be proven. Here, we show that muscle- and liver-specific AIF ablation in mice...
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