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An exercise-modifiable mitochondrial basis for skeletal muscle insulin resistance in humans

2025-12-19

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial dysfunction has long been associated with insulin resistance (IR), yet the causal relationship in humans remains unresolved. Here, to probe causality and delineate the underlying molecular mechanisms, we leveraged carriers of the m.3243A>G mtDNA variant as a human genetic model of primary mitochondrial dysfunction linked to diabetes. Deep metabolic phenotyping revealed selective sk...

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Literature Corpus work
f3578850-5ea6-53dd-bb11-0c915e4fcc40
DOI
10.64898/2025.12.17.25342274
Open publication

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An exercise-modifiable mitochondrial basis for skeletal muscle insulin resistance in humansDOI 10.64898/2025.12.17.25342274
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